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DeCS
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Descriptor English:
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25-Hydroxyvitamin D3 1-alpha-Hydroxylase
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Descriptor Spanish:
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25-Hidroxivitamina D3 1-alfa-Hidroxilasa
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Descriptor Portuguese:
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25-Hidroxivitamina D3 1-alfa-Hidroxilase
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Synonyms English:
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25-Hydroxycholecalciferol 1-Hydroxylase
CYP27B1
Calcidiol 1-Monooxygenase
Cytochrome P-450 CYP27B1
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Tree Number:
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D08.244.453.915.400
D08.811.682.690.708.170.915.400
D08.811.682.690.708.783.400
D12.776.422.220.453.915.400
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Definition English:
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A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol). |
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History Note English:
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2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002
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Allowable Qualifiers English:
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Record Number:
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7046
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Unique Identifier:
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D015090
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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